Green Synthesis of Pyrrole Derivatives

Synthesis of New Derivatives of Pyrrole Tuberculostatics Providing Structural Diversity

Nine pyrrole-containing compounds were designed introducing reasonable structural novelties within the framework of the architecture of confirmed tuberculostatics. The new products were synthesized via adopted Paal-Knorr cyclization by condensation of three 1,4-dicarbonyl compounds with a set of substituted anilines, acting as primary amines. Preliminary in vitro tests have already registered e...

Synthesis of certain pyrrole derivatives as antimicrobial agents.

In an effort to establish new pyrroles and pyrrolo[2,3-d] pyrimidines with improved antimicrobial activity we report here the synthesis and in vitro microbiological evaluation of a series of pyrrole derivatives. A series of new 2-aminopyrrole-3-carbonitriles (1a-d) were synthesized from the reaction of benzoin, primary aromatic amines and malononitrile, from which a number of pyrrole derivative...

Application of Green Chemistry in the Synthesis of Thiopyran Derivatives

An efficient synthesis of 2H-thiopyran derivatives via three-component reaction of alkyl propiolate, benzoyl isothiocyanate or its derivatives and alkyl bromides in the presence of triphenylphosphine in water at 80o C without using any catalyst in water is described. The method offers several advantages including high yields of products and an easy work-up procedure.

Hepatoprotective pyrrole derivatives of Lycium chinense fruits.

As a part of our search for hepatoprotective compounds from Lycium chinense fruits, three new pyrrole derivatives (1-3) were isolated. These compounds and a related synthetic methylated compound (4) were evaluated for their biological activity and structure-activity relationship, and compounds 1 and 2 showed hepatoprotective effects comparable to silybin at the concentration of 0.1 microM (64.4...

application of green chemistry in the synthesis of thiopyran derivatives